Single cell interaction networks

To apply, please email Iain with a brief description of your interests, a CV, and the names of three references.

Description: Central nervous system (CNS)-resident astrocytes, microglia, and neurons interact to regulate pro-inflammatory programs that drive neurodegenerative diseases, but the pathways and molecules involved are largely unknown. Understanding the language of inflammation is a central question in the field of Neuroimmunology and may guide new therapeutic approaches for neurologic diseases. We have developed new approaches to study cell-cell interactions, including CRISPR screens on cell pairs (SPEAC-seq), and barcoded rabies tracing methods (RABID-seq). We seek a talented postdoc to expand these approaches, and their applications, with the goal of understanding the genes, pathways, and molecules that control neuroinflammation.

Qualifications: The ideal candidate is a molecular biologist, immunologist, or neuroscientist interested in high throughput characterization of cellular interactions. Candidates must hold or be within 1 year of obtaining a PhD or MD/PhD.

Additional experience in the following areas is desired:

• Rabies tracing
• Disease models (MS, AD)
• Molecular immunology
• NGS (library prep, Illumina sequencing)
• Single cell sequencing
• Confocal microscopy