Tools for studying CNS inflammation
Central nervous system (CNS)-resident astrocytes and microglia interact to regulate pro-inflammatory programs that drive neurodegenerative diseases, but the pathways and molecules involved are largely unknown. Understanding the language of inflammation is a central question in the field of Neuroimmunology and may guide new therapeutic approaches for multiple sclerosis and other neurologic diseases. We are developing new methods to study the interactions between CNS-resident cells. Check out our most recent paper using barcoded rabies virus (RABID-seq), published in Science!
Current projects focus on:
- Barcoded viral tracing of cell-cell interaction in the CNS
- Genome-wide CRISPR screens for the discovery of genes that mediate cellular communication during inflammation