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HIV Latency

Infection with Human Immunodeficiency Virus (HIV) is incurable, despite drugs that effectively target the viral life cycle. The reservoir of cells containing replication-competent HIV that persists during drug therapy is poorly understood because these cells cannot be isolated to high purity. A major focus of the lab is isolating and sequencing latently infected CD4 T cells from people on long term effective anti-retorviral therapy.


Relevant Publications

  • HIV silencing and cell survival signatures in infected T cell reservoirs
  • Identification of astrocyte regulators by nucleic acid cytometry

Current projects focus on:

  • Application of FIND-seq to isolate and RNA-sequence rare HIV-infected T cells from people on ART
  • Extension of FIND-seq to study protein and epigenetic signatures of HIV-infected T cells

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