Research
Microfluidics
We build microfluidic and engineering tools for the high throughput analysis of single cells. We design new droplet microfluidic devices and assemble them into workflows for systems biology studies.
Cell-Cell Interactomics
We develop new methods to profile cell-cell interactions at scale. Current projects are focused on genome-wide CRISPR screens and viral tracing of CNS networks.
News
August 2026. Cyrille’s paper using DAb-seq to study the immunophenotype of HIV-infected cells is published in PNAS.
August 2026. Sakshi graduates with a PhD in Bioengineering. Congrats and good luck!
July 2026. Seung Won’s co-first preprint on ligand-receptor mapping with the Garcia lab is submitted
April 2026. James Named a 2026 Paul & Daisy Soros Fellow!
April 2026. Kevin graduates with a PhD in Bioengineering. Congrats and good luck at Triplebar!
March 2026. James receives the prestigious Paul & Daisy Soros Fellowship
October 2025. Kevin’s paper on deterministic cell pairing is published in Lab Chip.
April 2025. Iain becomes a Pew-Stewart Scholar
Jan 2024. The team is growing! Welcome to new postdocs Chenchen and Kang.
Sept 2023. Our MPI R01 with Ott, Murthy, Abate and Streets is funded.
Aug 2023. Iain is named as an Arc Innovation Investigator.
March 9, 2023. Our work using droplet-based CRISPR screens to identify mechanisms of astrocyte-microglia cross-talk is published in Science.
March 6, 2023. Our microfluidic-free scRNA-seq method (PIP-seq) is published in Nature Biotechnology.
Jan 4, 2023. Our paper, in collaboration with the Abate and Boritz Labs, is published in Nature.
Jan 4, 2023. Our droplet microfluidic method (FIND-seq) is published in Nature.
Join
Training and advancing people of all races and gender identities is a priority of this lab.
- Postdoc positions – Please email Iain with a brief description of your interests, a CV, and the names of three references.
- PhD Students – Students are encouraged to apply to the Berkeley/UCSF Graduate Program in Bioengineering and join the lab for a rotation.
- Undergraduates – Cal undergrads are encouraged to apply to projects posted on URAP. Due to the volume of inquiries, it may not always be possible to respond to email requests outside of this program.
Postdoc positions
Single cell profiling of HIV-infected cells
Our lab seeks to understand the molecular mechanisms that control HIV persistence. Specifically what, if any, are the unique properties of cells that harbor replication-competent HIV provirus during long-term antiretroviral therapy (ART)? We have developed a unique method to detect and sort HIV+ cells using ultra-high throughput droplet microfluidics. We seek a talented postdoctoral researcher to use this method to study HIV latency ex vivo.
Single cell interaction networks
We are interested in developing tools to map cellular connections in the mouse brain at a massive scale. Our approach is to combine virus tracing, molecular barcoding, and single-cell sequencing to study both the connections and transcriptional profiles of cellular networks. We seek a talented postdoctoral researcher to further develop and apply this method to new experimental systems and animal models of disease.
Contact
Clark Lab
Department of Bioengineering
University of California, Berkeley
392 Stanley Hall
Berkeley, CA 94720
Iain Clark, PhD
Assistant Professor, Bioengineering
University of California, Berkeley
Office: 374 Stanley Hall MC #3220
Berkeley, CA 94720
iain.c.clark [at] berkeley.edu